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Articles

JCI Editorials/Perspectives/Commentaries 2006

ISSUE PERSPECTIVE/COMMENTARY
1 December 2006 Vol.116;12
RNAi: a novel strategy for the treatment of prion diseases
Qingzhong Kong
Abstract | Full text | PDF (Page 3101)
Search for the preadipocyte progenitor cell
Gary J. Hausman, Dorothy B. Hausman
Abstract | Full text | PDF (Page 3103)
Selectins revisited: the emerging role of platelets in inflammatory lung disease
Wolfgang M. Kuebler
Abstract | Full text | PDF (Page 3106)
Proinsulin: a unique autoantigen triggering autoimmune diabetes
Sylvaine You, Lucienne Chatenoud
Abstract | Full text | PDF (Page 3108)
The sticky truth about angiogenesis and thrombospondins
Judith A. Varner
Abstract | Full text | PDF (Page 3111)


1 November 2006 Vol.116;11
Dysfunction of TGF-β signaling in Alzheimer’s disease
Pritam Das, Todd Golde
Abstract | Full text | PDF (Page 2855)
Microglia: a cellular vehicle for CNS gene therapy
Harald Neumann
Abstract | Full text | PDF (Page 2857)
Shaping the sperm head: an ER enzyme leaves its mark
Angshumoy Roy, Yi-Nan Lin, Martin M. Matzuk
Abstract | Full text | PDF (Page 2860)
The paradoxical patent ductus arteriosus
Kathryn N. Ivey, Deepak Srivastava
Abstract | Full text | PDF (Page 2863)
Role for IKK2 in muscle: waste not, want not
Michael Karin
Abstract | Full text | PDF (Page 2866)


1 October 2006 Vol.116;10
T cell activation altersintestinal structure and function
Michael Field
Abstract | Full text | PDF (Page 2580)
Pili prove pertinent to enterococcal endocarditis
Jonathan M. Budzik, Olaf Schneewind
Abstract | Full text | PDF (Page 2582)
Imaging tumor angiogenesis
Kristy Red-Horse, Napoleone Ferrara
Abstract | Full text | PDF (Page 2585)
Myeloid suppressor cells regulate the adaptive immune response to cancer
Alan B. Frey
Abstract | Full text | PDF (Page 2587)
To be or not to be B7
Xingxing Zang, James P. Allison
Abstract | Full text | PDF (Page 2590)
Children are not little adults: just ask their hematopoietic stem cells
David A. Williams, Haiming Xu, Jose A. Cancelas
Abstract | Full text | PDF (Page 2593)


1 September 2006 Vol.116;9
Commentaries
(1)A mighty mouse:building a better model of multiple sclerosis
(2)Regeneration of endothelium as a novel therapeutic strategy for acute lung injury
(3)Toll-like receptors and and IFN-alpha: partners in autoimmunity
(4)Chlesterol precursors and facial clefting
(5)Adaptibe human regulatory T-cells: myth or reality?
(6)You say estren, I say estrogen.Let's call the whole replacement off!
(7)Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxdidation and the NO resistance syndrome
1 August 2006 Vol.116;8
Commentaries
(1)Gout: new insights into an old disease
(2)What's i n a name? eNOS and anaphylactic shock
(3)HIV and CXCR4 in a kiss of autophagic death
(4)Costtimulation couture: a designer approach to regulating autoimmunity
(5)Misbehaving macrophages in the pathogenesis of psoriasis
(6)Tuning the oviduct to the anandamide tone
(7)The glomerular basement membrane: not gone, just forgotten
1 July 2006 Vol.116;7
Commentaries
(1)Tracking the recovery of consciousness from coma
(2)Arrythomogenic right  ventricular cardiomyopathy: moving toward mechanism
(3)Neuropetide signaling and hydrocephalus: SCO with the flow
(4)Liver X receptor opens new gateway to StAT and to steroid hormones
(5)New insights into the regulation of inflammation by adenosine
(6)Los and found: cardiac stem cell therapy revisited
(7)The leak stops here: platelets as delivery vehicles for coagulation factors
1 June 2006 Vol.116;6
Commentaries
(1)Cardiac hypertrophy: stressing out the heart
(2)Mechanisms of sympathoadrenal failiure and hypoglycemia in Diabetes
(3)IPEX and the roles of FOXP3 in the development and function of human Tregs
(4)Of mice,men, and elephants: Mycobaterium tuberculosis cell envelope lipids and pathogenesis
(5)Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance
(6)Cryptococcal virulence: beyond the usual suspects
1 May 2006 Vol.116;5
Commentaries
(1)Receptor heterodimerization: a new level of cross-talk
(2)An immunologic homunculus for type 1 diabetes
(3)Bypassing complement: evolutionary lessons and future implications
(4)The IL-23/IL-17 axis in inflammation
(5)Role of caveolin-1 in regulation of the vascular shear stress response
(6)Putting cholesterol in its place: apoE and reverse cholesterol transport
1 April 2006 Vol.116;4
Commentaries
(1)Adult T cell leukemia: a tale of two T cells
(2)Oxidative stress in sepsis:a redox redux
(3)The alchemy of tendon repair: a primer for the (S)mad scientist
(4)A new cardiac MASTer switch for the renin-angiotensin system
(5)Pathomechanisms in rheumatoid arthritis--time for a string theory?
(6)Ontogeny of adrenal steroid biosynthesis: why girls will be girls
(7)Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify,diversify,diversify
1 March 2006 Vol.116;3
(1)Going Nuclear in Metabolic and Cardiovascular Disease
(2)Estrogen receptors and human disease
(3)Sorting out the roles of PPAR-alpha in energy metabolsim and vascular homeostasis
(4)PPAR-gamma  and human metabolic disease
(5)PPAR: a dagger in the heart of the metabolic syndrome
(6)Invovlement of PPAR nuclear receptors in tissue injury and wound repair
(7)Liver X receptors as integrators of metabolic and inflammatory signaling
(8)PGC-1 coactivators: inducible regulators of energy metabolism in health and disease
1 February 2006 Vol.116;2
Commentaries
(1)SIDS: genetic and environmental influences may cause arryhthmia in this silent killer
(2)Gastrointesntinal motility and glycemia control in diabetes: the chicken and the egg revisted
(3)Insulin's effect on the liver:"Direct or indircet?" continues to be the question
(4)C5a and Fc-gamma receptors: a mutual admiration society
(5)Mucus in chronic airway diseases: sorting out the sticky details
1 January 2006 Vol.116;1
Commentaries
(1)Taking a bite out of hypertrophic cardiopmyopathy: soy diet and disease
(2)Gene expression profiling gets to the root of human hair follicle stem cells
(3)Delving deeper into MALT lymphoma biology
(4)Serum peptidome for cancer detection: spinning biologic trash into diagnostic gold
(5)Is the small heat shock protein alphaB-crystallin an oncogene?
(6)Inflamed fat; what starts the fire?