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Articles

JCI Editorials/Perspectives/Commentaries 2010

ISSUE PERSPECTIVES/COMMENTARIES
4 January 2010 Vol.120;1
Commentaries
(1)Putting the brakes on BTLA in T-cell mediated cancer immunotherapy
(2)Sodium channels gone wild: resurgent current from neuronal and muscle chennelopathies

(3)New roles for Notch in tuberous sclerosis

(4)Oxidant stress derails the cardiac connexon connection

(5)Ramping up RANTES in acute response to arterial injury



1 February 2010 Vol.120;2
Commentaries
(1)The role of genetic diversity in cancer
(2)RGF-beta pathogenesis and prevention of disease: a matter of aneurysmic proportions


1 March 2010 Vol.120;3
Commentaries
(1)New horizons for studying human hepatotropic infections
(2)Bidirectional homing of Tregs between the skin and lymph nodes

(3)A nonhuman primate model of chickengunya disease

(4)Lights on for amniopeptidases in cystic kidney disease

(5)Resisting arrest: a switch from angiogenesis to vasculogenesis in recurrent malignant gliomas


1 April 2010 Vol.120;4
Commentaries
(1)The role of Sirt 1 in renal rejuvenation and resistance to stress
(2)The one-two punch: knocking out angiotensin II in the heart

(3)Epithelial-mesenchymal transitions and hepatocarcinogenesis

(4)Monkeying around with cardiac progenitors: hope for the future

(5)Prevention trumps treatment of antibody-mediated transplant rejection

(6)Pathogen-specific antibodies: codependent no longer



1 May 2010 Vol.120;5
Commentaries
(1)Some new insights into molecular mechanisms of pain perception
(2)Neuronal injury:folate to the rescue?

(3)p63 and IRF6 brothers in arms against cleft palate

(4)Cryptococci at the brain gate: break and enter or use a Trojan horse?

(5)Caveat mTOR: aberrant signaling disrupts corticogenesis


1 June 2010 Vol.120;6
Commentaries
(1)Early tumor dissemination, but late metastasis: insights into tumor dormancy
(2)Gazing into crystal ball to predict kidney transplant outcome

(3)Revisiting an old acquaintance: role for eIF5A in diabetes

(4)Caught red-handed: uric acid is an agent of inflammation


1 July 2010 Vol.120;7
Commentaries
(1)Location,location,location: important for jet-lagged circadian loops
(2)An energetic  tale of AMPK-independent effects of metformin

(3)Radioprotection: smart games with death

(4)CA balancing act for autophagin

(5)Rapid progress for non-nuclear estrogen receptor signaling


8 August 2010 Vol.120;8
Commentaries
(1)Rehashing endocannabinoid antagonists; can we selectively target the periphery to safely treat obesity and type 2 diabetes
(2)Mice that "conditionally" lack basophils, AT LAST

(3)Seeing red: flushing out instigators of niancin-associated skin toxicity

(4)PIK3CA and KRAS mutations predict for response to everolimus therapy: now that's RAD001

(5)Semaphorin 3E, an exception to the rule

 

1 September 2010 Vol.120;9  
Commentaries
(1)New players in the sepsis-protective activated protein C pathway
(2)Fitness and freezing: vector biology and human health

(3)Too much PABP,too little translation

(4)Transgenic animals may help resolve a sticky situation in cystic fibrosis

(5)Reconstructing neural circuits using transplanted neural stem in the injured spinal cord

(6)Why antibodies disobey the Hippocratic Oath and end up doing harm: a new clue

(7)From skin cells to hepatocytes: advances in application of iPS cell technology

1 October 2010 Vol.120;10  
Commentaries
(1)Comeback kids: CD8* suppressor T cells are back in the game
(2)Location,location,regulation: a novel role for ß-spectrin in the heart

(3)In obesity and weight loss, all roads lead to mighty the macrophage

(4)c-Maf and you won't see fat

1 November 2010 Vol.120;11  
Commentaries
(1)Living or dying by RNA processing: caspase expression in NSCLC
(2)Pregnancy immunogentics: NK cell education in the womb?

(3)WT1: a weak spot in KRAS-induced transformation

(4)Are there more tricks in the bag for treating thrombocytopenia?

(5)New therapy to revert dysfunctional antibody responses during HIV-1 infection

(6)Pharmacologic eigenvalues: beating the rap on bone marrow failure

(7)The cellular response to hypoxia: tuning the system with micro RNAs

(8)The magic and mystery of miR-21

 1 December 2010 Vol.120;12  
Commentaries
(1) The RB tumor suppressor: a gatekeeper to hormone independence in prostate cancer?
(2)Which species are in your feces?

(3)Integral role of integrins in Th17 development

(4)A tincture of hepcidin cures all: the potential for hepcidin therapeutics

(5)Can TNF--α boost regulatory T cells?

(6)Can we build it better? Using BAC genetics to engineer more effective cytomegalovirus vaccines

(7)Is ryanodine receptor phosphorylation key to the fight or flight response and heart failure?

(8)Learning about genomics and disease from the anucleate human red blood cell